Less than three months after the selection of São Paulo, Brazil as the third city of the urban health initiative Better Hearts Better Cities, the Novartis Foundation announced the creation of a network of global and local implementation partners. They will co-design interventions to address São Paulo’s urban priorities to improve local cardiovascular health, including health education, lifestyle community programs, care coordination and standardization according to up-to-date clinical guidelines, and incorporating digital health tools into screening and care for high blood pressure.